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Titlebook: Dupuytren’s Disease; Pathobiochemistry an Alfred Berger,Axel Delbrück,Rolf Hinzmann Conference proceedings 1994 Springer-Verlag Berlin Heid

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書目名稱Dupuytren’s Disease
副標題Pathobiochemistry an
編輯Alfred Berger,Axel Delbrück,Rolf Hinzmann
視頻videohttp://file.papertrans.cn/284/283390/283390.mp4
圖書封面Titlebook: Dupuytren’s Disease; Pathobiochemistry an Alfred Berger,Axel Delbrück,Rolf Hinzmann Conference proceedings 1994 Springer-Verlag Berlin Heid
描述In this volume a distinguished group of internationallyrenowned clinicians and basic researchers discuss thepresent state of knowledge of the etiologyand pathogenesisof Dupuytren‘s contracture, a disease responsible foraconsiderable portion of disabilities within the workingpopulation allover the world. Although the riddle of howthe contracture of the palmarfascia develops is stillunsolved, the data on the pathobiochemistry andclinic ofDupuytren‘s Disease achieved in recent years has led to abetter understanding of the biochemical and morphologicalprocesses underlying the deformation and malfunction of theafflicted tissues.Research in Dupuytren‘s Disease nowenters the era of molecular medicine, which opens up newexperimental means of studying the pathologicalchangeswhich occur during the formation of the contracture onamolecular level. In particular, data are presented as to therole ofspecific biological macromolecules influencing thephenotype expression ofthe palmar fascia cells which areinvolved in autoimmune reactions andpresent both at thecell surface as well as in the extracellular matrix toregulate cell-to-cell and cell-to-matrix interactions. Invitro cell culture models to i
出版日期Conference proceedings 1994
關(guān)鍵詞Aetiology; Cellular Biology; Dupuytren‘s Disease; Extrazellul?re Matrix; Histopathologie; Histopathology;
版次1
doihttps://doi.org/10.1007/978-3-642-78517-7
isbn_softcover978-3-540-57239-8
isbn_ebook978-3-642-78517-7
copyrightSpringer-Verlag Berlin Heidelberg 1994
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Interactions Between Proteoglycans and Collagen Fibrils in the Palmar Fascia in Dupuytren’s Diseasehogenesis is not known, although many efforts has been made to describe the histology and biochemistry of Dupuytren’s tissue. In the nodules, the cells proliferate and differentiate to myofibroblasts (Gabbiani and Majno 1972, reviewed by Schürch et al. 1992) and the amount and types of collagen and
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Connective Tissue Autoantibodies in Dupuytren’s Disease: Associations with HLA DR3 [1]. This hypothesis was bolstered by Menzel et al. [2], who demonstrated the presence of circulating antibodies to collagen (ACA) in DC patients. These results were confirmed by Pereira et al. [3], showing a whole spectrum of autoantibodies to different collagen types in these patients. The mere d
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Proteoglycans in Biopsies of Dupuytren’s Contracutreert 1954). In the following four decades intensive investigations on the structure and function of these molecules resulted in the discovery of multiple forms and families of proteoglyans. Later studies more specifically defined what proteoglycans are. In 1982 proteoglycans were stated to be a group
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Fibroblast Gel Culture: A Model for Biochemical Investigations of Dupuytren’s Contracturey and metabolism of a distinct cell population involved in the pathogenesis of Dupuytren’s contracture, cell culture systems offer the opportunity to study metabolism independent of local or exogenous factors interfering with the regulation of cell functions. Monolayer cell cultures are widely used
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