Titlebook: Drugs between Research and Regulations; Proceedings of the 5 C. Steichele (Medizinischer Direktor),U. Abshagen Conference proceedings 1985

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Chronic toxicity tests, current problems and possible solutions humans are exposed for an extended period of time. Thus, the intention was not to study the acute toxic reactions, but rather the slowly developing lesions related to organ-directed toxicity, accumulation of the test substance or its metabolites in certain organs, functional and structural changes