Titlebook: Drug-Induced Liver Toxicity; Minjun Chen,Yvonne Will Book 2018 Springer Science+Business Media, LLC, part of Springer Nature 2018 Acute li

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Danica Damljanovi?,Kalina Bontchevaation and drug-induced liver injury. Many of these failed. The main two reasons are: (1) Methods are overly sensitive or unspecific and flag many drugs that show a safe history of use in a large population. (2) Reactive metabolite screening methods are too generic and fail to detect drug-specific bi

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In Vitro Assessment of Mitochondrial Toxicity to Predict Drug-Induced Liver Injury

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Detection, Elimination, Mitigation, and Prediction of Drug-Induced Liver Injury in Drug Discoveryphases of drug development. Considerable efforts are dedicated to the detection and understanding of idiosyncratic DILI, and to the prediction of intrinsic DILI. Ever more complex and biologically relevant in vitro models are emerging for compound prescreening purposes. These data are also being use

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