| 書目名稱 | Drug Transporters in Drug Disposition, Effects and Toxicity | | 編輯 | Xiaodong Liu,Guoyu Pan | | 視頻video | http://file.papertrans.cn/284/283142/283142.mp4 | | 概述 | Focusing on the roles of drug transporters in drug disposition, effects and toxicity.Introducing the cutting-edge developments in the study of drug transporters.Discussing the function and clinical si | | 叢書名稱 | Advances in Experimental Medicine and Biology | | 圖書封面 |  | | 描述 | .This book provides with a comprehensive overview of the role of drug transporters in drug disposition and efficacy/toxicity, as well as drug-drug interactions and recent advances in the field. Transporters are known determinants of drug disposition and efficacy/toxicity. In general, they are divided into solute carrier (SLC) and ATP binding cassette (ABC) families, and are located along cell membranes, where they mediate drug uptake into cells and export out of cells. Drug transporters are essential in maintaining cell homeostasis, and their?gene mutations may cause or contribute to severe human genetic disorders, such as cystic fibrosis, neurological disease, retinal degeneration, anemia, and cholesterol and bile transport defects. Conversely, some diseases may also alter transporter functions and expressions, in turn aggravating disease process. Further, since over-expression of some ABC transporters is a potential contributor to multidrug-resistance (MDR), the book presentsa number of strategies to overcome MDR, including ABC transporter inhibitors and applying epigenetic methods to modulate transporter expressions and functions.?This book is useful for graduate students and pr | | 出版日期 | Book 2019 | | 關鍵詞 | ATP binding cassette transporters; Solute carrier transporters; Drug-drug interaction; Blood-tissue bar | | 版次 | 1 | | doi | https://doi.org/10.1007/978-981-13-7647-4 | | isbn_softcover | 978-981-13-7649-8 | | isbn_ebook | 978-981-13-7647-4Series ISSN 0065-2598 Series E-ISSN 2214-8019 | | issn_series | 0065-2598 | | copyright | Springer Nature Singapore Pte Ltd. 2019 |
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書目名稱Drug Transporters in Drug Disposition, Effects and Toxicity影響因子(影響力)
書目名稱Drug Transporters in Drug Disposition, Effects and Toxicity影響因子(影響力)學科排名
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書目名稱Drug Transporters in Drug Disposition, Effects and Toxicity網絡公開度學科排名
書目名稱Drug Transporters in Drug Disposition, Effects and Toxicity被引頻次
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