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Titlebook: Drug Safety Evaluation; Methods and Protocol Jean-Charles Gautier Book 2017Latest edition Springer Science+Business Media LLC 2017 immunohi

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發(fā)表于 2025-3-21 16:54:02 | 只看該作者 |倒序瀏覽 |閱讀模式
書目名稱Drug Safety Evaluation
副標題Methods and Protocol
編輯Jean-Charles Gautier
視頻videohttp://file.papertrans.cn/284/283125/283125.mp4
概述Includes cutting-edge methods and protocols.Provides step-by-step detail essential for reproducible results.Contains key notes and implementation advice from the experts
叢書名稱Methods in Molecular Biology
圖書封面Titlebook: Drug Safety Evaluation; Methods and Protocol Jean-Charles Gautier Book 2017Latest edition Springer Science+Business Media LLC 2017 immunohi
描述.This second edition provides up-to-date chapters and new chapters focusing on the most recent advances in the field of drug safety evaluation. Divided into seven parts, chapters detail specific aspects related to the experimental design of preclinical studies conducted to support the safety of pediatric and combination drugs, necropsy and histopathology evaluation, mass spectrometry imaging, genetic toxicology protocols including the .Pig-a. mutation assay, safety pharmacology methods such as automatization of patch-clamp procedures, target safety assessment for investigative toxicology, screening assays for developmental toxicology, and methods to characterize novel translational safety biomarkers like microRNAs. Written in the highly successful .Methods in Molecular Biology .series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting to avoid known pitfalls..Authoritative and practical,. Drug Safety Evaluation: Methods and Protocols, Second Edition. aims to ensure successful results in the further study of this vital field..
出版日期Book 2017Latest edition
關鍵詞immunohistochemistry; mass spectrometry imaging; histopathology evaluation; Pig-a mutation; patch-clamp
版次2
doihttps://doi.org/10.1007/978-1-4939-7172-5
isbn_softcover978-1-4939-8406-0
isbn_ebook978-1-4939-7172-5Series ISSN 1064-3745 Series E-ISSN 1940-6029
issn_series 1064-3745
copyrightSpringer Science+Business Media LLC 2017
The information of publication is updating

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發(fā)表于 2025-3-22 00:11:20 | 只看該作者
A framework for describing work critical tissue samples may be stored for the subsequent evaluation. It is therefore important that the personnel in charge of this key experimental step to be adequately trained and aware of the study endpoints.
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A framework for describing work critical tissue samples may be stored for the subsequent evaluation. It is therefore important that the personnel in charge of this key experimental step to be adequately trained and aware of the study endpoints.
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發(fā)表于 2025-3-22 17:16:08 | 只看該作者
Changing requirements for work performanceidentify either spontaneous or diseases-induced changes. Routinely, tissues are fixed with neutral formalin 10%, embedded in paraffin, and manually sectioned with a microtome to obtain 4–5 μm thick paraffin sections. Dewaxed sections are then stained with HE&S (hematoxylin-eosin and saffron) or can
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發(fā)表于 2025-3-22 23:15:53 | 只看該作者
A framework for describing work and specific and can detect a wide variety of antigens in multiple animal species. This chapter reviews common immunohistochemical methods used in the characterization of normal and pathologic tissue and the reagents used. Pretreatments such as blocking steps for endogenous activities and antigen r
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發(fā)表于 2025-3-23 03:52:45 | 只看該作者
Practices and Orientations of CSCL in biology. Developed over 50 years ago, and with different principles to detect and map compounds on a sample surface, MSI supports modern biology questions by detecting biological compounds within tissue sections. MALDI (matrix-assisted laser desorption/ionization) imaging trend analysis in this
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發(fā)表于 2025-3-23 06:58:12 | 只看該作者
Designing Sociable CSCL Environmentsdogenous . gene of treated rats by using flow cytometry to measure changes in cell surface markers of peripheral blood cells. Here we present a methodology for demonstrating that phenotypically mutant rat T-cells identified by flow cytometry contain mutations in the . gene, an important step for val
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