Titlebook: Drug Resistance in Leishmania Parasites; Consequences, Molecu Alicia Ponte-Sucre,Emilia Diaz,Maritza Padrón-Niev Book 20131st edition Sprin

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Genetic Expression and Drug Resistance, the Role of Proteomicsis. However, since in ., the control of gene expression relies on the stability or processing of the mature mRNA, as well as on the posttranslational modifications of proteins, the genomic sequences alone are insufficient to predict protein expression within the parasites. In this scenario, proteomi

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The Role of ABC Transporters in Drug-Resistant ,nt in prokaryotes and eukaryotes and are mainly involved in the transport of a variety of molecules across cellular membranes, whereas others are involved in biological processes unrelated to transport. The recent sequencing of the . species genome confirmed the presence of representatives, also cal

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Functional Analysis of , Membrane (Non-ABC) Transporters Involved in Drug Resistancese transporters also serve as routes for uptake of drugs used for treatment of leishmaniasis or experimental drugs with potential for development of novel anti-leishmanial therapies. Hence, mutations within the coding regions of such permeases or alterations in the expression of the carrier proteins

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,Religionswissenschaftliche Hinführung,ues for better treatments may help improve this depressing picture. Experts in the field cover current knowledge and future trends of these and many other aspects of drug resistance in . in the present volume. This part offers a general introduction to the biology of ., a piece of knowledge fundamen

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A.S. Ginevsky,A. I. Zhelannikov and genetically isolated populations in all . species tested so far. A predominantly clonal evolution has been proposed for . with rare sexual recombination events. This hypothesis has repeatedly been challenged by the detection of hybrids, mosaic genotypes, and gene flow between populations, stron

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,Die Entwickelung der Zünfte in Deutschland,ented, with a particular emphasis on their relation with parasite drug resistance. The focus of this chapter is on antimonials since we have most experience in the field and in the lab with them. Although these drugs are currently being abandoned as first-line treatment in the Indian subcontinent, w

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