Titlebook: Drug Resistance in Leishmania Parasites; Consequences, Molecu Alicia Ponte-Sucre,Maritza Padrón-Nieves Book 2018Latest edition Springer Int

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Wilfried Roetzel,Bernhard Spang causes of these treatment failures are still not fully comprehended, but they are most likely a consequence of the complex interplay between parasite, host and drug. In this chapter, the generally accepted underlying factors of treatment failure are discussed along with their consequences for therapy, drug design and other related challenges.

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Leishmaniasis: The Biology of a Parasite,emergence of leishmaniasis, as well as its death and disability-adjusted life year toll worldwide. A better understanding of the disease itself and of drug resistance, its molecular basis, its consequences, and the definition of possible paths for better treatments may help improve this depressing p

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Molecular Evolution and Phylogeny of is, in which the parasites evolved from a monoxenous ancestor on Gondwana and separated into Paraleishmania and all other species around the time when Gondwana split..Many molecular markers have demonstrated substantial intraspecies diversity and the existence of geographically and genetically isola

Synchronism

The Role of Reservoirs: Canine Leishmaniasisnce not all infected animals develop signs of disease. This fact cannot be ignored since asymptomatic (without clinical signs) dogs are infectious to phlebotomine vectors, although at a lower risk than symptomatic (with clinical signs) dogs. The fact that dogs never achieve parasitological cure toge

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American Tegumentary Leishmaniasisnd for control of the disease. The present chapter offers a description of American tegumentary leishmaniasis. a fundamental piece of knowledge for the comprehension of the challenges we face for leishmaniasis in times of drug resistance. As a way to better understand the unique scenario that Americ

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The Role of Proteomics in the Study of Drug Resistanceiles of . spp. reveal changes in protein expression during development, determine the subcellular localization of gene products, evaluate host-parasite interactions, and elucidate drug resistance mechanisms. The characterization of these proteins has advanced, although many fundamental questions rem