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Titlebook: Drug Receptors and Their Effectors; Biological Council S Nigel J. M. Birdsall Conference proceedings 1981Latest edition Macmillan Publisher

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樓主: 宗派
41#
發(fā)表于 2025-3-28 18:06:47 | 只看該作者
https://doi.org/10.1057/9781137029256ite the identification and characterisation of a plethora of responses elicited by muscarinic agonists in whole cells and tissues (Birdsall and Hulme, 1976), the nature of the membrane macromolecules with which the receptor interacts . has, until recently, been more a matter for speculation than of firm evidence.
42#
發(fā)表于 2025-3-28 22:21:52 | 只看該作者
Victor Dudman‘s Grammar and Semanticswithin the membrane which finally lead to the characteristic response of the cell. Recent work in our laboratory has shown that the methylation of phospholipids are important events in the receptor-mediated transmission of signals through membranes.
43#
發(fā)表于 2025-3-29 01:00:50 | 只看該作者
44#
發(fā)表于 2025-3-29 03:19:45 | 只看該作者
Robert K. Garcia,Nathan L. Kingused on the channel associated with the acetylcholine receptor in the postsynaptic membrane of the nicotinic synapse. For several decades this junction has provided advances in our understanding of synaptic transmission.
45#
發(fā)表于 2025-3-29 08:55:32 | 只看該作者
46#
發(fā)表于 2025-3-29 11:48:03 | 只看該作者
https://doi.org/10.1057/9781137020406tion of drugs resulted from their physicochemical interaction with a defined site. At that time this principle was revolutionary and presaged the development of modern pharmacology, starting with the classification of different drug receptors (see, for example, Dale, 1914) and the quantitation of dr
47#
發(fā)表于 2025-3-29 19:22:46 | 只看該作者
48#
發(fā)表于 2025-3-29 19:59:25 | 只看該作者
https://doi.org/10.1057/9781137029256detailed knowledge of the properties of the binding site, particularly in the brain (Hulme ., 1978; Birdsall ., 1978, 1980.; Galper ., 1977), and despite the identification and characterisation of a plethora of responses elicited by muscarinic agonists in whole cells and tissues (Birdsall and Hulme,
49#
發(fā)表于 2025-3-30 01:18:18 | 只看該作者
https://doi.org/10.1057/9781137029256 reviews see Reynolds and Randall, 1957; Lewis ., 1971; Clouet, 1971, Winter, 1975; Kosterlitz ., 1973). However, with the exception of studies indicating a presynaptic action of opiates which prevents Ca.-dependent transmitter release and the more recent findings of a postsynaptic action of opiates
50#
發(fā)表于 2025-3-30 04:54:51 | 只看該作者
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