Titlebook: Drug Dosing in Obesity; Volume I: Antimicrob Syed Tabish R. Zaidi,Jason A. Roberts Book 2016 Springer International Publishing Switzerland

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Aminoglycoside Dosing in Obesity,ccurate initial dosing regimens can be achieved by using a correction factor for obesity when estimating a volume of distribution (V). While for subsequent doses, therapeutic drug monitoring (TDM) remains an essential tool to guide dosing and to prevent unwanted adverse events such as nephrotoxicity.

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Azole Antifungal Agents, advancements in drug delivery, efficacy, monitoring and side effect profiling. Pharmacokinetic changes and dose guidance for these agents in the obese population will be addressed following a review of the available literature.

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Penicillins, sepsis. Clinical efficacy and the prevention of the emergence of resistance are critically dependent upon the correct dosing strategy in order to meet the required time-dependent pharmacodynamic target. Penicillins mainly experience increases in volume of distribution and renal clearance in obese p

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Cephalosporins,nfections. Compared with other antibiotics such as vancomycin and aminoglycosides, there is a paucity of data on the pharmacokinetics of cephalosporins in obesity and dosing recommendations are scarce. The purpose of this chapter is to review and summarise the published data to assist in developing

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Fluoroquinolones,age form. The pharmacokinetics of this particular class of antibiotics varies significantly among individual agents, thus preventing a uniform approach to dose adjustment. Relatively more data is available for ciprofloxacin and levofloxacin compared to other agents in this class. This chapter outlin