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Titlebook: Drug Discovery and Evaluation: Pharmacological Assays; Franz J. Hock Reference work 2016Latest edition Springer International Publishing S

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發(fā)表于 2025-3-21 18:54:23 | 只看該作者 |倒序瀏覽 |閱讀模式
書目名稱Drug Discovery and Evaluation: Pharmacological Assays
編輯Franz J. Hock
視頻videohttp://file.papertrans.cn/284/283078/283078.mp4
概述Covers classical and cutting-edge technologies, including methods & assessment of relevance.Updates readers with some 1,000 assays in an easy-to-use and uniform Format.Guides readers on testing and ev
圖書封面Titlebook: Drug Discovery and Evaluation: Pharmacological Assays;  Franz J. Hock Reference work 2016Latest edition Springer International Publishing S
描述The 4th edition of this successful reference book contains an updated selection of the most frequently used assays for reliably detecting the pharmacological effects of potential drugs. Effects covered include cardiovascular, analgesic, endocrine, psychotropic, respiratory, renal and immunomodulatory activities. Each of the more than 1,000 assays comprises a detailed protocol outlining the purpose and rationale of the method, a critical assessment of the results and their pharmacological and clinical relevance. In addition, animal models of rare diseases are described. For this 4th edition, all existing chapters have been revised and completely updated. A large number of assays were added. Sections that have been specifically enlarged include - Pharmacological assays in thrombosis and haemostasis, - Antidiabetic activity (includes completely new chapters such as Biochemical Methods in Diabetology), - Anti-atherosclerotic activity. New chapters are added such as Auditory Pharmacology, Oncology Activity, Stem Cells, Omics, Personalized Medicine, etc.
出版日期Reference work 2016Latest edition
關(guān)鍵詞assays; drug action; drugs; pharmacological tests; toxicology
版次4
doihttps://doi.org/10.1007/978-3-319-05392-9
isbn_ebook978-3-319-05392-9
copyrightSpringer International Publishing Switzerland 2016
The information of publication is updating

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Stefano Caracciolo,Matteo BalestrieriThe test is used to detect the effect of compounds on blood pressure and heart rate of anesthetized rats and to check for possible interference with adrenergic receptors. Antihypertensive agents with different mechanisms of action can be detected with this test.
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https://doi.org/10.1007/978-90-313-7661-2Eschenhagen et al. (1997) developed a method for culturing embryonic cardiomyocytes in a collagen matrix to produce a coherently contracting three-dimensional model heart tissue that allows direct measurement of isometric contractile force.
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Studies in Isolated OrgansAngus and Wright (2000) described in detail various techniques to study the pharmacodynamics of isolated large and small blood vessels.
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Cardiovascular Analysis In VivoThe test is used to detect the effect of compounds on blood pressure and heart rate of anesthetized rats and to check for possible interference with adrenergic receptors. Antihypertensive agents with different mechanisms of action can be detected with this test.
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發(fā)表于 2025-3-23 08:05:24 | 只看該作者
Anti-Arrhythmic ActivityGuidelines for the study of arrhythmias in man and animals regarding the experimental design as well as the classification, quantification, and analysis were given as the Lambeth Conventions by Walker et al. (1988).
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