Titlebook: Drug Discovery; A Casebook and Analy Robert A. Maxwell,Shohreh B. Eckhardt Book 1990 Springer Science+Business Media New York 1990 calcium.

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eally does not happen as a spontaneous sequel to investiga- tive research, no matter how penetrating such research may be. Rather, it seemed to us that the discovery of innovative therapeutic agents was a very active process, existing in and of itself, and demanding full attention-it was not simply

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Azathioprinethat there was virtually no chance for success: the host’s immune system rejected and destroyed the donated organ (Medawar, 1944,1945; Dempster, 1953; Hume et al., 1955). Hume et al. (1955) concluded, “Renal homo- transplantation has no place in the therapy of human patients at this time.”

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https://doi.org/10.1007/978-3-663-12941-7nce, extracellular volume maintenance, and blood-pressure regulation. Moreover, some clinicians believe that it is the most significant advance yet in the diagnosis and management of hypertension (Laragh, 1984).

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https://doi.org/10.1007/978-3-663-12947-9 decreased rate of renal excretion of Na., the primary extracellular cation (Weiner and Mudge, 1985). Associated with this retention of Na. is the retention of extracellular anion (to maintain electroneutrality) and a volume of water adequate to maintain normal osmolality.