Titlebook: Drug Delivery to the Brain; Physiological Concep Margareta Hammarlund-Udenaes,Elizabeth C.M. de Lan Book 20141st edition American Associati

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Drug Discovery Methods for Studying Brain Drug Delivery and Distribution., equilibrium dialysis-based brain homogenate and brain slice methods, are described. The assessment of extent of BBB transport and intracellular distribution of NCEs, the identification of intra-brain distribution patterns, and their integration with pharmacodynamic measurements are valuable imple

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Prediction of Drug Exposure in the Brain from the Chemical Structuren, but also indicated no dependence on lipophilicity. The challenges associated with obtaining high predictivity models for K. confirm the contemporary view of the blood–brain barrier (BBB) as not only being physical and passive in nature but also involving specific carrier-mediated processes. It fo

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Pharmacoeconomic Considerations in CNS Drug Developmentthe commercial aspects of the technology and the requirements attached to the funding mechanisms for clinical development. Early choices about delivery modality and target therapy (indication) have important consequences for the development process. An understanding of the forces that currently driv

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Intranasal Drug Delivery to the Brainbutes of the nasal mucosa and its associated cranial nerves that allow small but significant fractions of certain intranasally applied drugs to transfer across the nasal epithelia and subsequently be transported directly into the CNS. We also review the preclinical and clinical literature related to

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Book 20141st edition affect drug action. This book describes small and large drug delivery to the brain with an emphasis on the physiology of the BBB and the principles and concepts for drug delivery across the BBB and distribution within the brain. It contains methods descriptions for studying drug delivery, routes an

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https://doi.org/10.1007/978-3-662-62050-2n, but also indicated no dependence on lipophilicity. The challenges associated with obtaining high predictivity models for K. confirm the contemporary view of the blood–brain barrier (BBB) as not only being physical and passive in nature but also involving specific carrier-mediated processes. It fo