Titlebook: Drug Delivery System; Kewal K. Jain Book 2014Latest edition Springer Science+Business Media, New York 2014 chemical engineering.drug deliv

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Vorposten der Gesundheitspflegeo bypass the blood–brain barrier to reach the central nervous system. The presented chapter highlights the method of intranasal delivery in mice using chitosan–siRNA nanoparticle formulation, under mild anesthesia and the identification of successful siRNA delivery in the brain tissues, through hist

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https://doi.org/10.1007/978-3-662-37803-8 described as well as devices used for drug delivery and targeted drug delivery. There has been a considerable increase in the number of new biotechnology-based therapeutics. Most of these are proteins and peptides, and their delivery presents special challenges. Cell and gene therapies are sophisti

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https://doi.org/10.1007/978-3-662-37803-8erapeutic drug targets and mitochondrial therapy would be expected to be useful for the treatment of various diseases. We have already reported the development of a MITO-Porter, a liposome-based nano-carrier that delivers its cargo to mitochondria via a membrane-fusion mechanism. In our strategy for

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https://doi.org/10.1007/978-3-662-37803-8 an attractive option. This novel platform technology uses gas-filled, ultrasound-directed acoustic microspheres for both diagnostic imaging and therapy and yet may provide a key component for future success in the pursuit of single-gene replacement therapy.

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https://doi.org/10.1007/978-3-662-37803-8bis-acrylamide (MBA) has been described in this chapter. The copolymers have been formed at different concentrations of NIPAM and VP and at two different temperatures (70 °C and 30 °C). The lower critical solution temperature (LCST) of the samples has been measured, and the size of the particles for

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https://doi.org/10.1007/978-3-662-37803-8tic biomaterials have been developed to mimic the natural extracellular matrix (ECM) for therapeutic use. These include synthetic polymers, decellularized ECM, self-assembling polymers, and cell-responsive hydrogels with varied applications. Here, we describe the development of a self-assembling pep

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https://doi.org/10.1007/978-3-662-37803-8xytamoxifen (4-Hydroxytam), and endoxifen (Endox) with chitosan nanoparticles of different sizes (chitosan-15, chitosan-100, and chitosan-200 KD) in order to evaluate the efficacy of chitosan nanocarriers in drug delivery systems. Spectroscopic and molecular modeling studies showed the binding sites