Titlebook: Drug Absorption Studies; In Situ, In Vitro an Carsten Ehrhardt,Kwang-Jin Kim Book 2008 Springer-Verlag US 2008 Assessment.Expression.Transp

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Diskurstheorie als Forschungsperspektive regulating drug distribution is key to the future of design of therapeutic agents that are safe for use in pregnancy. Reviewed herein are in vitro model systems for studying placental transport as well as consideration of some of the well-represented multidrug resistance transporters naturally expressed in this unique tissue.

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https://doi.org/10.1007/978-3-658-40590-8ort proteins, such as P-glycoprotein. Regulatory mechanisms underlying P-glycoprotein expression and function will be discussed. Ex vivo and in vitro models are introduced and methods to study drug permeation across the endothelial cell barrier will be described.

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In Vitro Screening Models to Assess Intestinal Drug Absorption and Metabolismmultitude of parameters, a single universal model accounting for all these parameters does not exist. Therefore, combination of different in vitro models should be considered in order to obtain better insights in intestinal drug absorption in the different phases of drug discovery and development.