Titlebook: Drug Absorption Studies; In Situ, In Vitro an Carsten Ehrhardt,Kwang-Jin Kim Book 2008 Springer-Verlag US 2008 Assessment.Expression.Transp

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In Vitro Screening Models to Assess Intestinal Drug Absorption and Metabolismted site of action. Different models have been established for the parallel screening of these biopharmaceutical properties, including membrane-based models (PAMPA), cell culture-based models (such as Caco-2 and MDCK cell lines), and the Ussing chambers technique. In this chapter, the strengths and

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In Vitro Cellular Models for Nasal Drug Absorption Studiesations, reliable in vivo and/or in vitro models are needed. In vivo animal models or in vitro excised animal tissue models are frequently used for nasal drug absorption studies due to various methodological and ethical limitations associated with the use of human nasal specimens. However, there are

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In Vitro Models of the Tracheo-Bronchial Epitheliumlveolar region). The conducting airways can be further subdivided into the trachea plus larger bronchi and the distal bronchiolar airways. Each of these regions consists of distinct types of epithelial cells with unique phenotypes, morphologies and associated physiological functions. This chapter fo

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In Vitro Models of the Alveolar Epithelial Barrierand macromolecules, including recently engineered peptide and protein therapeutics. Advantages of aerosol administration include a more rapid absorption into the systemic circulation (this may be particularly important for drugs where fast onset of action is critical), a higher bioavailability than

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Regulation of Paracellular Permeability in Low-Resistance Human Vaginal-Cervical Epitheliamposed of the tight junctional resistance (.TJ) and the resistance of the lateral intercellular space (.LIS). Recent studies in human vaginal-cervical epithelia revealed novel mechanisms of regulation of the paracellular resistance (.PCR), including both the .TJ and the .LIS. Steroid hormones and pa

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