Titlebook: Dopamine and Sleep; Molecular, Functiona Jaime M. Monti,S. R. Pandi-Perumal,S. Chokroverty Book 2016 Springer International Publishing Swit

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Klaus Bengler,Julia Drüke,Alexandra Neukumom clinicians and researchers but now these symptoms are known to be significant predictors of morbidity, quality of life, costs of disease, and rates of institutionalization. A discussion of the clinical aspects, pathophysiology, evaluation techniques and treatment options for sleep disorders encountered with PD are presented.

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Dopaminergic Transmission and Wake-Promoting Effects of Central Nervous System Stimulants,, amphetamines and modafinil, are potent wake-promoting substances in mammals and even in invertebrates such as . In mammals, the cell bodies of dopamine neurons controlling the sleep-wake cycle are located in the midbrain and brainstem. Midbrain dopamine neurons express high levels of DAT and play

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The Effects of Dopamine Receptor Agonists on the Sleep-Wake Cycle,obiological functions controlled by DA, including the sleep-wake cycle, are mediated by the DA family, which comprises D., D., D., D. and D.?receptors. From the pharmacological point of view, compounds that bind and activate DA receptors?are significant means for the study of mechanism of action of

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Functional Interactions Between MCHergic and Dopaminergic Neurons: Role in the Control of Wakefulney both in the nucleus accumbens and prefrontal cortex during rapid-eye-movement (REM) sleep; this DAergic activity has been involved in the generation of dreams. The melanin-concentrating hormone (MCH) is a peptide with neuromodulatory functions synthesized by neurons located in the postero-lateral

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Modulations of Ventral Tegmental Area (VTA) Dopaminergic Neurons by Hypocretins/Orexins: Implicatiotems will be discussed. We will first overview the (1) neurobiology of wakefulness and (2) symptoms of narcolepsy, followed by discoveries of the hcrt/ox system and hcrt/ox deficiency in narcolepsy. We will then discuss the functional links between the VTA DAergic and hcrt/ox systems, by introducing

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Alteration of Biological Rhythms in Diseases of the Central Dopaminergic System: Focus on Parkinsonerations in activity, temperature and heart rate rhythms have been observed in several animal models of PD. Deposition of alpha-synuclein in the hypothalamic suprachiasmatic nuclei (SCN) (i.e, the site of central oscillator) has been detected in transgenic mice and altered rhythms in clock genes hav