Titlebook: Diseases of the Liver in Children; Evaluation and Manag Karen F. Murray,Simon Horslen Book 2014 Springer Science+Business Media New York 20

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Normal Functional Biology of the Liver populated with multiple cell types, including hepatocytes, cholangiocytes, stellate cells, endothelial cells, and cells of the immune system (i.e., Kupffer cells). Each cell type performs unique functions essential to the overall performance of the liver. A full treatise of each cell and function i

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Laboratory Assessment of Hepatic Injury and Functionver relies on a multidisciplinary approach involving clinical chemistry, hematology, immunology, imaging studies, endoscopy, histopathology, and microbiology. Mutational analyses for many genetic liver diseases are now available. This chapter will outline the basic laboratory assessment of the liver

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Phenotypes of Liver Diseases in Infants, Children, and Adolescentsthey read about during their training but may never have encountered. The aim of this chapter is to describe hepatic disease phenotypes based on age and primary manifestation of liver disease such as cholestasis, hepatomegaly, or acute liver failure and to provide a reasonably comprehensive list of

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Psychosocial, Cognitive, and Quality of Life Considerations in the Child with Liver Disease and Theidiatric patients with liver disease demonstrate deficits in IQ that typically persist even after liver transplantation. This may be related to prolonged hospitalizations and malnutrition that often occur in this population. Research on other cognitive domains are ongoing but have demonstrated simila

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Neonatal Hemochromatosis and Gestational Alloimmune Liver Diseaseconsequence of severe fetal liver disease. Gestational Alloimmune Liver Disease (GALD) is the cause of fetal liver injury leading to nearly all cases of NH. The mechanism of GALD involves maternal IgG alloantibodies directed against a fetal hepatocyte antigen. Fetal complement is bound and the termi