Titlebook: Disease Gene Identification; Methods and Protocol Johanna K.‘DiStefano Book 2018Latest edition Springer Science+Business Media, LLC 2018 bi

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Nik Norulaini Nik Ab Rahman,Norizan Esagenesis, thereby challenging the concept that protein-coding genes are the sole contributors to the development of human disease. This chapter highlights recent findings linking lncRNAs with human diseases of complex etiology, including hepatocellular carcinoma, Alzheimer’s disease, and diabetes.

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Quo Vadis, Environmental Management?culture, expansion, selection, and differentiation of AECs, which allow the robust generation of a bulk edited AEC population from transduced cells. Applying these methods, we detail here our latest protocol to generate mucociliary epithelial cultures knocked out for a specific gene from donor-isola

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1064-3745 ation advice from the experts.This volume presents detailed laboratory procedures in an easy to follow format that can be carried out with success by investigators lacking previous exposure to a specific research method. Chapter guide readers through the application of molecular approaches to diseas

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Book 2018Latest editions exposure to a specific research method. Chapter guide readers through the application of molecular approaches to disease gene identification and overviews, ?and case studies are also presented. Written in the highly successful .Methods in Molecular Biology .series format, chapters include introduc

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Sustainable Living with Environmental Risksor therapeutic intervention. Here, we describe a basic workflow, from sample preparation to data analysis, for performing a GWAS to identify disease genes. We also discuss resources for the annotation and interpretation of GWAS results.

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Wolf-Rüdiger Bretzke,Karim Barkawippropriate quality control measures for sequencing on the Illumina HiSeq2000 platform. Additional modifications to the protocol for long insert WGS library construction, to assess structural alterations and copy number changes, are also described.

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Rishi Ranjan Singh,Daya Ram Gaurable information for both discovery research and precision medicine applications. In this chapter, we present a WES library preparation protocol using the KAPA Hyper Prep Kit with Agilent SureSelect Human All Exon V5+UTR probes that demonstrates high DNA-to-library conversion efficiency for sequencing on the Illumina HiSeq platform.