Titlebook: Discoidin Domain Receptors in Health and Disease; Rafael Fridman,Paul H. Huang Book 2016 Springer Science+Business Media New York 2016 can

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,Stahl – Herstellung, Verwendung, Schutz,llagenous ECM following chronic injury. Fibrosis from persistent injury may progress to cirrhosis, an end-stage lesion, which may lead to liver failure and death. Research is focused on receptor tyrosine kinases (RTKs) as new targets for antifibrotic therapies. Among them, discoidin domain receptors

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https://doi.org/10.1057/9780230294608family isoforms, are single-pass transmembrane proteins, containing the discoidin (DS) domain and the DS-like domain on the extracellular side, and an extremely long juxtamembrane region and the kinase domain on the intracellular side. This chapter provides an overview of the structural knowledge of the DDR receptors.

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Book 2016tissue differentiation and function. At the cellular level, organ homeostasis depends on a productive communication between cells and ECM, which eventually leads to the normal phenotypic repertoire that characterize each cell type in the organism. ?A failure to establish these normal interactions an

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Small Molecule Inhibitors of Discoidin Domain Receptors (DDRs)nhibitors have been discovered in recent years. This chapter will provide an updated overview on the chemical structures, mechanism of action (MOA), and potential medical implications of the newly identified DDR small molecule inhibitors.

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Discoidin Domain Receptors in Lung Cancer from these studies are inconsistent and sometimes contradictory, which may be explained by differences in the use of analytic methods, the retrospective nature of study reports, and differences in biospecimen procurement, storage, and processing.

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