Titlebook: Digital Twins; Applications to the Christoph Herwig,Ralf P?rtner,Johannes M?ller Book 2021 The Editor(s) (if applicable) and The Author(s)

LIMIT

Numerical Methods for the Design and Description of In Vitro Expansion Processes of Human Mesenchymational Fluid Dynamics (CFD) which has become widely used in the biotech industry for studying local characteristics within bioreactors or kinetic growth modelling, provide possible solutions for such tasks..In this review, we will present the current state-of-the-art for the in vitro expansion of h

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Euler-Lagrangian Simulations: A Proper Tool for Predicting Cellular Performance in Industrial Scalect gradients; high-shear regions are among the most interesting factors that can be reproduced adequately with help of a digital twin. In this chapter basic principles of this method will be introduced, and later on some practical aspects of particle tracking technique will be illustrated. In the fi

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Potential of Integrating Model-Based Design of Experiments Approaches and Process Analytical Technoeterogeneities. Therefore, the scaling of such processes from laboratory to industrial scale and vice versa is not a trivial task. Traditional scale-down methodologies consider several technical parameters, so that systems on the laboratory scale tend to qualitatively reflect large-scale effects, bu

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Numerical Methods for the Design and Description of In Vitro Expansion Processes of Human Mesenchymmmatory diseases), especially in the field of regenerative medicine. However, for autologous (patient-specific) and allogeneic (off-the-shelf) hMSC-based therapies, in vitro expansion is necessary prior to the clinical application in order to achieve the required cell numbers. Safe, reproducible, an