Titlebook: Difficult To Treat Asthma; Clinical Essentials Sandhya Khurana,Fernando Holguin Book 2020 Springer Nature Switzerland AG 2020 asthma.diffic

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Evaluation and Management of Work-Related Asthma,dity and increasing medication requirements for asthma. In a patient with confirmed asthma, the clinical history that includes key questions for work-related asthma has a high sensitivity for the diagnosis. However, objective tests are needed to confirm a diagnosis of sensitizer-induced occupational

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Biomarkers, Targeted Therapies, Biologics, and Bronchial Thermoplasty,er of biologic therapies. Our understanding of the mechanisms that drive severe asthma has been rapidly evolving over the last decade, revealing multiple pathologic mechanisms that can result in similar asthma symptoms and disease activity. Concurrently, there has been a dramatic change in the appro

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Practical Considerations in the Management of Eosinophilic Asthma, predominantly driven by the eosinophil. Quantitative sputum cytometry is the most validated and sensitive test for diagnosis of eosinophilic asthma. Other biomarkers, including blood eosinophils, immunoglobulin (Ig) E, fraction of exhaled nitric oxide (FeNO), and periostin, have also been used as s

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Practical Considerations in Management of Non-eosinophilic Asthma, Noneosinophilic asthma can be further subdivided by predominant inflammatory cell types: neutrophilic, mixed granulocytic, and paucigranulocytic asthma. Patients with non-eosinophilic asthma represent approximately half of all asthma cases in adults and have been shown to have the full spectrum of

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Severe Asthma in Childhood: Special Considerations,poor airways growth. This chapter distinguishes severe asthma from asthma that is difficult to control and is due to diagnoses masquerading as asthma, comorbid conditions that make asthma worse, or nonadherence to medication regimen. Two main phenotypes of severe childhood asthma include (1) highly