| 書目名稱 | Diagnostic and Therapeutic Antibodies | | 編輯 | Andrew J. T. George,Catherine E. Urch | | 視頻video | http://file.papertrans.cn/271/270738/270738.mp4 | | 概述 | Includes supplementary material: | | 叢書名稱 | Methods in Molecular Medicine | | 圖書封面 |  | | 描述 | Soon after the first description of monoclonal antibodies in 1976, there was enormous interest in the clinical application of antibodies, especially in the context of cancer. Antibodies appeared to offer the “magic bullet” that would allow the specific destruction of neoplastic cells. H- ever, many years’ effort resulted in very few cases of successful immu- therapy with antibodies. As a result there was a major backlash against antibody therapy, and the field lost a considerable amount of popularity. Fashion, in science as well as in other things, tends to be cyclical. Antibody-based therapy is once again attracting scientists and clinicians. There are several reasons for the renewed optimism; certainly the expe- ence of the last two decades has provided a wealth of information about problems associated with antibody therapy, and possible solutions to these problems. Recombinant antibody engineering has rejuvenated the field, allowing both the modification of antibodies to improve their in vivo pr- erties and the isolation of novel antibody molecules by such techniques as phage display. The results of recent clinical trials have demonstrated unequivocally the benefit of antibody t | | 出版日期 | Book 2000 | | 版次 | 1 | | doi | https://doi.org/10.1385/1592590764 | | isbn_softcover | 978-1-61737-195-0 | | isbn_ebook | 978-1-59259-076-6Series ISSN 1543-1894 Series E-ISSN 1940-6037 | | issn_series | 1543-1894 | | copyright | Humana Press 2000 |
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