Titlebook: Diagnosis and Management of Autoimmune Hepatitis; A Clinical Guide Mark W. Russo Book 2020 Springer Nature Switzerland AG 2020 AIH.liver in

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Helmut Schmalen,Herbert Lang,Hans PechtlALF) requiring liver transplantation. AIH can affect all populations and age groups, and has diverse clinical phenotypes and outcomes that vary between groups. Clinical, laboratory, and histologic manifestations may mimic many other liver diseases, thus AIH is often considered in the patient with ac

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Martin Benkenstein,Antje Bastianen developed to objectively categorize histologic features as compatible with or atypical for autoimmune hepatitis depending on the presence of prominent plasma cells, interface hepatitis, emperipolesis, and hepatocyte rosette formation, although newer studies have called into question the specifici

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Martin Benkenstein,Antje Bastian a biochemical remission. Combination therapy during induction with subsequent tapering of steroids with the intent of maintaining remission with azathioprine monotherapy is the goal. A majority of patients with AIH are capable of attaining a remission with first-line therapy and can be cautiously c

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Martin Benkenstein,Antje BastianIgG), and autoantibodies in the absence of a known etiology. Untreated, the condition often progresses rapidly to cirrhosis..In children, autoimmune liver disorders can be divided into three different types: autoimmune hepatitis (AIH), autoimmune sclerosing cholangitis (ASC), and de novo autoimmune

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Sigrid Bekmeier-Feuerhahn,Heiner Spiekertcome of the pregnancy. Patients and physicians must balance the benefits of maintaining good control of disease activity with potential risks to the fetus of immunosuppressive medications. Women with autoimmune hepatitis have an increased risk of pre-term birth and infants who are low birth weight

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Kommanditgesellschaft auf AktienT) may be needed for AIH patients who present with acute liver failure without a prior diagnosis of AIH or in those who develop decompensated liver disease despite medical therapy. The proportion of all AIH that present as acute hepatitis that may progress to liver failure and need transplantation r

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https://doi.org/10.1007/978-981-19-8734-2mphoplasmocytic inflammation on liver biopsy. Differentiating between DILI and idiopathic autoimmune hepatitis (iAIH) can be challenging in part because it is often difficult to establish DILI causality. Drug discontinuation is the main treatment of DILI with autoimmune features, though immunosuppre

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Treating the Adult Patient: Alternative Drug Therapies,Standard therapy for autoimmune hepatitis can be limited by drug intolerance or inadequate biochemical response. After optimizing drug doses and excluding noncompliance, alternative immunosuppressive agents need to be considered. This chapter will review the role of second-line agents in the treatment of autoimmune hepatitis.