Titlebook: Developmental and Reproductive Toxicology; Ali S. Faqi Book 2017 Springer Science+Business Media LLC 2017 Teratology.Animal models.Drug-dr

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Book 2017ative methods to assess potential developmental toxicity for drugs and chemicals, and effects of chemicals on testes and mammary glands. Evaluation of developmental and reproductive toxicology endpoints is an integral part of the safety assessment process for compounds with potential use in women of

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,Metabolism and Drug–Drug Interaction in Pregnant Mother/Placenta/Fetus,es that takes place during pregnancy coupled together with the variety in the responses of the cytochrome P450 enzymes in terms of induction and inhibition as well as the presence of polymorphic forms which may be present and the influence of the drug transporters make predicting the pharmacokinetic

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Nonclinical Safety Assessment of Developmental and Reproductive Toxicology: Considerations for Condals and biopharmaceuticals. A brief history of the regulatory perspective of drugs which provides background to the current study designs presented in the chapter is discussed. The initial FDA guidelines and the subsequent International Conference on Harmonisation (ICH) S5(R2) currently used for the

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Effects of Chemicals on Mammary Gland Development,tructure. Unlike most organs, the mammary gland has several critical periods of growth and development after birth, and is only fully developed after a full-term pregnancy. Mammary gland development is dependent on complex endocrine signaling as well as paracrine and autocrine signaling between the

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Using the Alternative Model , in Reproductive and Developmental Toxicology Studies,onths in rodent to many years in humans. A proper execution of the male and female reproductive programs is therefore crucial for the production of viable gametes and the propagation of species. Mounting evidence highlights the exquisite sensitivity of reproductive pathways to environmental influenc