Titlebook: Developmental Toxicology; Keith Snell Book 1982 Keith Snell 1982 drug.environment.toxicology

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Biochemical Mechanisms of Teratogenesis,the problems in this field on an interdisciplinary basis (Bass ., 1970). Also, in a relatively young science like teratology where a large mass of experimental data has now been gathered, but where the theoretical basis of the subject still consists of little more than half a dozen ‘rules of thumb’

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The Differentiation of Drug Metabolism in Relation to Developmental Toxicology,he mother is the most significant route for the fetus to eliminate foreign chemicals and because this diffusion is thought to be most rapid for unchanged lipid-soluble substances. If, however, the fetus should metabolise foreign substances to more watersoluble metabolites, these metabolites might ac

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Developmental Enzyme Pathology, frank congenital malformations, prenatal toxicity may also manifest itself as functional aberrations, such as behavioural or biochemical abnormalities, which may remain latent before being expressed at later stages of development. It follows from the nature of the defect that such functional abnorm

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Book 1982erapeutic agents could cause damage to the developing organism, but the absence of any known examples of drug-induced birth defects had produced an air of complacency which was reinforced by the lack of any specific regulatory requirements for safety evaluation in this area. The magnitude of the tha

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