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Titlebook: Development of In-Tether Carbon Chiral Center-Induced Helical Peptide; Methodology and Appl Kuan Hu Book 2021 Springer Nature Singapore Pte

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發(fā)表于 2025-3-21 19:04:19 | 只看該作者 |倒序瀏覽 |閱讀模式
書目名稱Development of In-Tether Carbon Chiral Center-Induced Helical Peptide
副標(biāo)題Methodology and Appl
編輯Kuan Hu
視頻videohttp://file.papertrans.cn/270/269970/269970.mp4
概述Nominated as an outstanding PhD thesis by Peking University.Reports on important progress in the study of stabilized peptide drugs.Introduces applications in cancer stem cell therapy and self-assembly
叢書名稱Springer Theses
圖書封面Titlebook: Development of In-Tether Carbon Chiral Center-Induced Helical Peptide; Methodology and Appl Kuan Hu Book 2021 Springer Nature Singapore Pte
描述.This book focuses on the development of stapled peptides, a novel molecular modality used to regulate aberrant intracellular protein–protein interactions (PPIs). The author designs and presents a novel helical peptide stabilization methodology by constructing a chiral cross-linker moiety, namely “chiral center induced peptide helicity (CIH)”. The book demonstrates that a precisely positioned carbon chiral center on tether can decisively determine the secondary structure of a peptide, and that the R-configured peptide is helical, while the S-configured peptide is non-helical. Further, it reports that helicity-enhanced R isomer peptides displayed significantly enhanced cell permeability and target binding affinity, as well as tumor inhibition efficiency, in comparison to S isomer peptides. The book will not only advance readers’ understanding of the basic principle of stapled peptides, but also accelerate the clinical transformation of stapled peptide drugs.?.
出版日期Book 2021
關(guān)鍵詞Stabilized peptide; Staple peptide; Chirality; Cell permeability; Helicity; Protein-protein interactions;
版次1
doihttps://doi.org/10.1007/978-981-33-6613-8
isbn_softcover978-981-33-6615-2
isbn_ebook978-981-33-6613-8Series ISSN 2190-5053 Series E-ISSN 2190-5061
issn_series 2190-5053
copyrightSpringer Nature Singapore Pte Ltd. 2021
The information of publication is updating

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沙發(fā)
發(fā)表于 2025-3-21 23:11:44 | 只看該作者
Development of In-Tether Carbon Chiral Center-Induced Helical PeptideMethodology and Appl
板凳
發(fā)表于 2025-3-22 02:36:57 | 只看該作者
地板
發(fā)表于 2025-3-22 04:33:24 | 只看該作者
Synthesis of In-Tether Chiral Center Peptides and Their Biophysical Properties Study,areas and shallow surfaces. Therefore, the development of constrained peptides that can modulate PPIs by enhancing the helicity of short peptides is important. Many strategies have been developed and successfully applied. Early approaches to stabilize an α-helix involved both polar and physiological
5#
發(fā)表于 2025-3-22 12:11:33 | 只看該作者
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發(fā)表于 2025-3-22 14:00:56 | 只看該作者
Jacques Hagenaars,Hans-Jürgen Andre?areas and shallow surfaces. Therefore, the development of constrained peptides that can modulate PPIs by enhancing the helicity of short peptides is important. Many strategies have been developed and successfully applied. Early approaches to stabilize an α-helix involved both polar and physiological
7#
發(fā)表于 2025-3-22 20:12:36 | 只看該作者
8#
發(fā)表于 2025-3-22 23:34:51 | 只看該作者
Kuan HuNominated as an outstanding PhD thesis by Peking University.Reports on important progress in the study of stabilized peptide drugs.Introduces applications in cancer stem cell therapy and self-assembly
9#
發(fā)表于 2025-3-23 05:01:42 | 只看該作者
10#
發(fā)表于 2025-3-23 08:26:36 | 只看該作者
Antwortskalenrichtung und UmfragemodusProtein-protein interactions (PPIs) play important roles in cell life activities, such as signal transduction, cell cycle, immune system, gene regulation, and so on.
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