| 書目名稱 | Development of Chemistry-Based Screening Platform for Access to Mirror-Image Library of Natural Prod |
| 編輯 | Taro Noguchi |
| 視頻video | http://file.papertrans.cn/270/269955/269955.mp4 |
| 概述 | Nominated as an outstanding Ph.D. thesis by Kyoto University.Describes a pioneering chemistry-based screening process for drug discovery.Provides valuable insights for the field of organic chemistry, |
| 叢書名稱 | Springer Theses |
| 圖書封面 |  |
| 描述 | .This thesis mainly describes the development of a screening process for a mirror-image library of chiral natural products. It demonstrates how, by using mirror-image proteins for the screening of available natural products, unavailable mirror-image isomers of natural products can be screened in a mirror process. Moreover, as mirror-image isomers including target proteins and natural products are mainly prepared by means of chemical synthesis, the screening strategy presented here suggests the importance of organic chemistry. .Natural products are commonly used as valuable resources for drug discovery. However, as they are mostly produced as single enantiomeric forms, researchers have tested o.nly natural products bearing one stereochemistry available in nature. As natural products and their enantiomers have identical physicochemical properties and different biological activities, mirror-image isomers of natural products are promising candidates for novel medicinal resources. . In an effort to identify anticancer agents from the mirror-image library, chemical protein syntheses of some target oncoproteins, MDM2, MDMX and Grb2, and their applications to the chemical array screening p |
| 出版日期 | Book 2018 |
| 關鍵詞 | Mirror-Image Protein Technology; Total Synthesis of Natural Products; Total Synthesis of Proteins; Natu |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-981-10-6623-8 |
| isbn_softcover | 978-981-13-4917-1 |
| isbn_ebook | 978-981-10-6623-8Series ISSN 2190-5053 Series E-ISSN 2190-5061 |
| issn_series | 2190-5053 |
| copyright | Springer Nature Singapore Pte Ltd. 2018 |
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