Titlebook: Development of Antibody-Based Therapeutics; Translational Consid Mohammad A. Tabrizi,Gadi G. Bornstein,Scott L. Kla Book 2018Latest edition

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Novel Technologies for Generation of Bispecific Constructs,te-of-the-art engineering, production, and development of recombinant protein scaffolds, development of novel bispecific modalities has witnessed an exponential growth. In this chapter the current landscape for bi- and multi-specific modalities from design, production, and developability aspects is discussed.

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Translational Biomarkers: Application in the Clinical Development of Combination Therapies,ade are ongoing. The discussions in this chapter are focused on the use of current and emergent biomarkers in the design and development of treatment combinations for cancer, with a special emphasis on emerging IO therapies.

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Introduction,tion of antibody-drug conjugates. We hope that this collection has successfully captured new advances relevant to the development of targeted therapeutics and will provide interested reader with an advanced knowledge of the field.

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Application of Proof-of-Mechanism Biomarkers (POM) in Design and Development of Biologics Modalitietibody pharmacokinetics (PK) and ensuing effects on biomarkers can be effectively examined. Evaluation of exposure–response relationships in vivo can provide invaluable information with respect to antibody potency and pharmacodynamic response efficiency.