Titlebook: Detection of Non-Amplified Genomic DNA; Giuseppe Spoto,Roberto Corradini Book 2012 Springer Science+Business Media Dordrecht 2012 Enhanced

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Recent Advances in Sequencing Technologydes the ability to resequence thousands of human genomes a year. While the current methods of choice utilize amplification-based methods and the corresponding challenges of sample preparation that accompany these methods, new technologies that do not require amplification have emerged. Single-molecu

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Engineered Nanostructures for the Ultrasensitive DNA Detections the existing issues of conventional DNA detection assays. The basic principles, advantages, and limitations of engineered nanostructure-amplified DNA detection methods will be introduced and discussed.

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Advanced Molecular Probes for Sequence-Specific DNA Recognitionion of unamplified DNA will be discussed in this chapter. Chemistry and architectures for conjugation of probes to reporter units, surfaces and nanostructures will also be discussed. Examples of probes used in ultrasensitive detection of unamplified DNA are listed.

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