Titlebook: Desmoid Tumors; Charisse Litchman Book 2012 Springer Science+Business Media B.V. 2012 APC.Aggressive Fibromatosis.Desmoid Tumor.Familial A

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Charisse LitchmanFirst manuscript on desmoid tumors.World renowned authors.Encompasses topics of relevance to clinicians, scientific researchers and advocacy groups.Provides concrete guidance for treatment planning.Ad

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Carcinogen

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Gabler Wirtschaftsw?rterbuch Russischor these neoplasms. The APC/β-catenin pathway is known to be deregulated in DT. This chapter illuminates the molecular mechanisms of APC/β-catenin pathway signaling, elucidates the potential deregulations and mutations at play in DTs, and most importantly evaluates the possible implications of this pathway on DT diagnosis, prognosis, and therapy.

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Clinical Presentation of Desmoid Tumorsh as Familial Adenomatous Polyposis (FAP). Despite the absence of metastatic potential, DT may cause debilitating symptoms and in some cases life-threatening organ damage because of their locally invasive nature. DT may range from small slow-growing masses to rapidly enlarging aggressive tumors. The

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Pathology of Desmoid Tumorssually straightforward but can be difficult in small biopsies and in recurrences associated with scars from a prior procedure. Immunohistochemistry, specifically β-catenin, and more recently, molecular diagnostics can play an important role in its diagnosis. This chapter reviews the clinical and pat

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APC/β-Catenin Deregulation in Desmoid Tumors: Important Implications for Diagnosis, Prognosis, and Tor these neoplasms. The APC/β-catenin pathway is known to be deregulated in DT. This chapter illuminates the molecular mechanisms of APC/β-catenin pathway signaling, elucidates the potential deregulations and mutations at play in DTs, and most importantly evaluates the possible implications of this