Titlebook: Design, Analysis, and Interpretation of Genome-Wide Association Scans; Daniel O. Stram Book 2014 Springer Science+Business Media New York

certain

出血

Maryam Sultana,In Su Kim,Soon Ki Jungthods discussed in Chap. 4, (3) multi-staged genotyping designs, (4) fine-mapping of associations using multi-marker analyses, (5) power calculations for haplotype analysis and imputed marker analysis, and (7) reuse of existing data for new studies.

使迷醉

Maryam Sultana,In Su Kim,Soon Ki Jung currently being evaluated for large-scale association studies. The main raison d’être for WGS is to allow for interrogation of rare variation that cannot be measured on GWAS SNP arrays used to date. This chapter covers some of statistical topics related to the assessment of the role of rare variati

該得

Topics in Quantitative Genetics,display, by ., of leading principal components that characterize global population structure..Many parts of the broader field of population genetics are entirely ignored here. Notably we do not discuss, except parenthetically, natural selection as a force determining allele frequency distributions w

chance

bronchiole

Haplotype Imputation for Association Analysis,tainties in the estimation of the haplotype frequencies that underlie the imputation of haplotypes, the chapter also considers simultaneous maximum likelihood estimation of all parameters (risk estimates and haplotype frequency estimates), so that haplotype uncertainty is formally taken account of i

邊緣帶來(lái)墨水

Junction

Design of Large-Scale Genetic Association Studies, Sample Size, and Power,thods discussed in Chap. 4, (3) multi-staged genotyping designs, (4) fine-mapping of associations using multi-marker analyses, (5) power calculations for haplotype analysis and imputed marker analysis, and (7) reuse of existing data for new studies.

兇兆

pancreas