Titlebook: Design and Delivery of SiRNA Therapeutics; Henrik J. Ditzel,Martina Tuttolomondo,Sakari Kaupp Book 2021 Springer Science+Business Media, L

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,Engineering of Solid Dosage Forms of siRNA-Loaded Lipidoid–Polymer Hybrid Nanoparticles Using a Qua-glycolic acid) to effectively deliver siRNA directed against tumor necrosis factor alpha (TNF-α) intracellularly to macrophages. L. is a novel lipid-like material consisting of a tetraamine backbone linked to five C. alkyl chains. Here, we describe a systematic quality-by-design (QbD) approach incl

Coronary

Cell-Penetrating Peptides Delivering siRNAs: An Overview,thesis, use, and versatility. Recent progress with siRNA delivered by CPPs seems to focus on targeted delivery to reduce side effects and amount of drugs used, and it appears to be among the most promising use for CPPs in future clinical applications.

Generic-Drug

盤旋

siRNA Vehicles for High Endosomal Escapability, a highly required characteristic for the induction of a high knockdown effect. Here, we describe the step-by-step procedure for the evaluation of high endosomal escapability. The vector that has pH-responsive characteristics at around pH?=?6.2–6.5 is important for the high endosomal escape.

盤旋

siRNA Design and Delivery Based on Carbon Nanotubes,he past decade. The assay described in this chapter allows for realizable quantification of siRNA binding on carbon nanotube-based materials using gel electrophoresis and silencing by flow cytometry when the siRNA complexes are delivered in vitro.

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