Titlebook: Design and Analysis of Vaccine Studies; M. Elizabeth Halloran,Ira M. Longini,Claudio J. St Book 2010 Springer-Verlag New York 2010 Biostat

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M. Elizabeth Halloran,Ira M. Longini,Claudio J. St

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Introduction and Examples, similar range. He compared these values with his analysis of the relation of recovery from smallpox with smallpox vaccination, which were in the range 0.576 and 0.769. Although he demurred somewhat due to his lack of knowledge about typhoid, he wrote that the results were such as “would justify sus

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Binomial and Stochastic Transmission Models,on a number produced by a random number generator described later..In Chapter 5 we present simple differential equation transmission models that are generally deterministic. That is, every time the equations are solved, the same answer is obtained. This approach is essential to understanding large c

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Evaluating Protective Effects of Vaccination,ns in asymptomatic people, an active follow-up method of testing asymptomatic people is needed..In this chapter we consider estimation and inference for direct protective effects of vaccination, VE. and VE., in studies that do not condition on exposure to infection.We consider aspects of the design

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Modes of Action and Time-Varying VE,% of the vaccinated people. Would you behave differently if you knew which of these possibilities were actually true? Would it make a difference if the vaccine were against a disease with a high case fatality ratio?Would it make a difference if the efficacy were 60% rather than 90%?.In Chapter 6, va

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