Titlebook: Deciphering Growth; Jean-Claude Carel,Paul A. Kelly,Yves Christen Conference proceedings 2005 Springer-Verlag Berlin Heidelberg 2005 IGF r

審問

Genetic Control of Size at Birth,lood pressure indicate that other maternal genes could influence size at birth in first pregnancies, where risk of pre-eclampsia is greatest. In subsequent pregnancies, gestational diabetes is linked to increased risk of macrosomia, and the impact of higher maternal glucose levels on larger offsprin

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The GH/IGF-1 Axis: Insights from Animal Models,f the IGF-1R gene. In our mutant mice, the postnatal growth of males relied more strongly on IGF-1R levels than the growth of females. Experiments using tissue-specific IGF-1R inactivation in the central nervous system provided evidence that IGF signaling in the brain may play a key role during the

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jagged

IGF Resistance: The Role of the Type 1 IGF Receptor,ozygote for missense mutations in the ligand binding domain. These mutations lowered the affinity of the IGF receptor for IGF-I and attenuated receptor signaling. The other child had a stop codon in exon 2 and showed a reduction in cell surface IGF receptor abundance. Though specific mutations withi

Vertebra

Evolutionary Trends in Body Size,scale trends in body size evolution. Bergmann’s Rule is the tendency for warm-blooded species at high latitudes to be larger than their close relatives nearer the equator. The Island Rule is the trend for small species to become larger, and large species smaller, on islands. Cope’s Rule, which we di

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Sexual Dimorphism in the Growth of ,: Facts, Inferences and Speculation,commonly larger, and greater male body mass and height are typical of primates. Growth of ., however, is characterized by a number of unusual features, including rapid . growth, a prolonged childhood phase, a pubertal spurt in stature, and a relative lack of sexual dimorphism, with adult male height

babble

WAG

Coeval

fixed-joint

Growth Hormone Receptor Signaling and Differential Actions in Target Tissues Compared to IGF-I,ignal transduction pathways differ - GH: associated tyrosine kinase (Jak) that activates signal transducers and activators of transcription (Stat) transcription factors; IGF-I: intrinsic tyrosine kinase that activates insulin receptor substrate (IRS) docking proteins, involved in several down stream