Titlebook: Data Mining in Structural Biology; Signal Transduction I. Schlichting,U. Egner Conference proceedings 2001 Springer-Verlag Berlin Heidelbe

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Structural Basis for Substrate Recognition and Control in Protein Kinases,yrosine residues results in a number of different responses that include activation of enzyme activity, inhibition of enzyme activity, protein/protein recognition and association, protein/protein dissociation, and sub-cellular targeting. Consistent with their key roles in cellular signalling process

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The Selectivity of Small Molecules Towards Protein Tyrosine Kinases,oteins inolved in human cancers. Enhanced PTK activity is also implicated in nonmalignant proliferative diseases, such as psoriasis, papilloma, re-stenosis, and pulmonary fibrosis. These findings have led to an enormous surge over the past decade in studies aimed at targeting PTKs for drug developme

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Elements of Signal Transduction in Drug Discovery with Special Reference to Inhibitors of Protein Kmortality as a whole has remained almost unchanged during the last two decades despite enormous worldwide efforts. This is particularly surprising in view of the tremendous progress that has been achieved during the last 20–25 years with regard to our understanding of the molecular mechanisms underl

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,The Berlin “Protein Structure Factory” Initiative: A Technology-Oriented Approach to Structural Genement of a “working draft” of the human genome sequence (Macilwaine 2000). This major publicity event followed closely completion of the DNA sequencing of the two smallest human chromosomes (Dunham et al. 1999; Hattori et al. 2000). In addition, a rapidly growing number of DNA sequences representing

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