Titlebook: DNA-Encoded Chemical Libraries; Methods and Protocol David Israel,Yun Ding Book 2022 Springer Science+Business Media, LLC, part of Springer

纖細(xì)

Yongbin Zhang,Xiuli Fu,Li Wei,Yanying ZhengDNA-compatible C-H activations expand the chemical space of DNA-encoded library. Here we describe the ruthenium-promoted C-H activation between DNA-conjugated acrylamides and aromatic acid.

conceal

Tim Schlippe,Eric C. K. Cheng,Tianchong WangCondensation of imines with anhydrides has been proven to be a valuable method for the synthesis of tetrahydroisoquinolines. Herein, we describe the application of this chemistry with DNA-conjugated imines. It is proven to be an efficient way to deliver isoquinolone chemotypes for DNA-encoded library.

galley

On-DNA Reductive Amination and Alkylation,On-DNA reductive amination (on-DNA aldehyde with amine building blocks) and alkylation (on-DNA amine with aldehyde building blocks) are robust ways to form C-N bond. The large sets of commercially available aldehyde and amine building blocks make reductive amination and alkylation widely used in DEL synthesis.

玩忽職守

obsession

On-DNA Suzuki-Miyaura Cross-Coupling,Suzuki-Miyaura cross-coupling is one of the most widely employed reactions in medicinal chemistry. Here we describe the efficient cross-coupling with on-DNA halide substrates using Pd(PPh.). as coupling catalyst.

安撫

preservative

Ruthenium-Promoted On-DNA C-H Activation Reaction,DNA-compatible C-H activations expand the chemical space of DNA-encoded library. Here we describe the ruthenium-promoted C-H activation between DNA-conjugated acrylamides and aromatic acid.

BADGE

Condensation of DNA-Conjugated Imines with Homophthalic Anhydride for the Synthesis of IsoquinoloneCondensation of imines with anhydrides has been proven to be a valuable method for the synthesis of tetrahydroisoquinolines. Herein, we describe the application of this chemistry with DNA-conjugated imines. It is proven to be an efficient way to deliver isoquinolone chemotypes for DNA-encoded library.

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978-1-0716-2547-7Springer Science+Business Media, LLC, part of Springer Nature 2022