Titlebook: DNA Vaccines; Methods and Protocol Douglas B. Lowrie,Robert G. Whalen Book 2000 Springer Science+Business Media New York 2000

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Artificial Intelligence and Soft Computingsponse; live infectious agents and inactivated or subunit vaccine preparations. Live infectious agents generally are most efficacious, but there is always a risk factor when using this type of vaccine. The major advantage of inactivated and subunit preparations is their safety; however, limited effi

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Artificial Intelligence and Soft Computingof cancer, autoimmunity, and allergy (.). Until recently, however, the cellular events by which injected plasmid DNA elicits potent antibody and cytotoxic T-lymphocyte (CTL) responses were largely unknown. Upon intramuscular (i.m.) injection of naked DNA, predominant expression of transfected DNA oc

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Artificial Intelligence and Soft Computinglate and deliver purified plasmid DNA into mouse tissues. They discovered that direct injection of lipid-DNA complexes into muscle resulted in measurable protein expression. A belated control experiment without lipid led to the serendipitous discovery that “naked” plasmid DNA was taken up and expres

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Artificial Intelligence and Soft Computing induce markedly stronger CD8. cytotoxic T lymphocyte (CTL) activity than do traditional peptide vaccines through their particular mechanism of antigen presentation mediated by MHC class I molecules. Induction of CTL specific to pathogenic viruses is thought to provide a reliable means of protecting