Titlebook: DNA Topoisomerases and Cancer; Yves Pommier Book 2012 Springer Science+Business Media, LLC 2012 Tyrosyl-DNA-Phosphodiesterase.Ubiquitin.an

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Hamza Hamout,Abderrahmane Elyousfi generated DNA damage. These newly identified genes will be important in understanding the repair processes that occur with this unique type of DNA damage, and promise to provide new markers for predicting the therapeutic efficacy of this important class of anticancer drugs.

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Rian Dolphin,Barry Smyth,Ruihai Dongr in the presence of drugs such as camptothecin causes DNA damage that must be repaired if the cell is to survive. The list of proteins known to interact with Top1 suggests that the enzyme has functions . that extend well beyond the previously characterized roles in replication, transcription, and chromatin assembly.

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Georgios N. Yannakakis,Julian Togeliuslication machinery that may contribute to CPT toxicity, while recent biochemical, genetic, and genome-wide studies provide novel insights into mechanisms regulating the stability of replication forks and recombinational processing of replicative lesions in CPT-treated cells.

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