Titlebook: DNA Topoisomerase Protocols; Volume II: Enzymolog Neil Osheroff,Mary-Ann Bjornsti Book 2001 Humana Press 2001

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Topoisomerase II-Catalyzed ATP Hydrolysis as Monitored by Thin-Layer Chromatography,ic functions (.–.). ATP binding is necessary to close the protein clamp (.,.) and trigger DNA strand passage (.,.), whereas hydrolysis is necessary for topoisomerase II recycling (.,.). Beyond the the critical roles played by ATP in the catalytic cycle of the enzyme, interactions between type II top