Titlebook: DNA Repair of Cancer Stem Cells; Lesley A Mathews,Stephanie M Cabarcas,Elaine M. Hu Book 2013 Springer Science+Business Media Dordrecht 20

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Resistance and DNA Repair Mechanisms of Cancer Stem Cells: Potential Molecular Targets for Therapy,l therapies leading to tumor recurrence and metastasis. A majority of cancers initially respond to chemotherapeutic agents, as well as radiation therapy, but eventually develop resistance. An increased understanding of CSCs has led to the discovery that current treatments target the differentiated c

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DNA Repair in Normal Stem Cells,ype of somatic cell and play essential roles during development, whereas multipotent stem cells produce a limited number of closely related cell types and are responsible for tissue homeostasis during an organism’s lifetime. It is essential for stem cells to maintain genomic integrity, as alteration

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DNA Repair Mechanisms in Other Cancer Stem Cell Models, rise to all the mature cells of a tissue. DNA damage constantly arises from DNA replication, spontaneous chemical reactions and assaults by external or metabolism-derived agents. Therefore, all living cells must constantly contend with DNA damage. It is particularly crucial for survival of organism

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https://doi.org/10.1007/978-3-030-15504-9reak repair, which comprise both homologous recombination and non-homologous end-joining. Although a complex set of cellular responses are elicited following DNA damage, this chapter provides an introduction to the specific molecular mechanisms of recognition, removal, and repair of DNA damage.

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DNA Repair Pathways and Mechanisms,reak repair, which comprise both homologous recombination and non-homologous end-joining. Although a complex set of cellular responses are elicited following DNA damage, this chapter provides an introduction to the specific molecular mechanisms of recognition, removal, and repair of DNA damage.