Titlebook: DNA Repair Mechanisms and Their Biological Implications in Mammalian Cells; Muriel W. Lambert,Jacques Laval Book 1989 Springer Science+Bus

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Art, Literature, and Passions of the Skiesng the compounds to which Mex. cells are sensitive are the alkylnitrosamines and alkylnitrosamides which can form covalent adducts with cellular DNA at the O.-position of guanine. A particularly important class of such compounds is the cross-linking nitrosoureas which are widely used in chemotherapy

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Luk Bouckaert,Knut J. Ims,Peter Ronaong the induced products there are DNA repair functions and proteins required for mutagenesis. For mammalian cells, formally a similar response has been detected. New gene products are synthesized (Herrlich, ., 1986). No DNA repair induction has yet been characterized although it is likely that it e

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https://doi.org/10.1007/978-3-319-00801-1tive damage to DNA (both base and sugar damage). Yet, the nature and relative rates of the reactions involving active oxygen species make it difficult to ascertain, in each particular situation, what reactants may act as the predominant genotoxicant and what DNA repair mechanisms may ensue.

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Public Artifacts, Intentions, and Normsh ultraviolet radiation (UV) . and transfected into xeroderma pigmentosum (XP) and repair proficient human cells. Replicated episomal plasmids were harvested and assayed for survival and mutations by transforming indicator bacteria. Plasmids with mutated . gene yield white or light blue colonies aft

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Catecholamines in the Carotid Bodyt that most chemical carcinogens are active only after metabolism to an ultimate carcinogenic and mutagenic form. These ultimate carcinogens tend to be electron deficient and thus react with nuclephilic sites which are abundant in DNA. It has been established that B[a]P is metabolized by the mixed f

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