| 書(shū)目名稱(chēng) | DNA Polymorphisms as Disease Markers | | 編輯 | D. J. Galton,G. Assmann (Director) | | 視頻video | http://file.papertrans.cn/261/260172/260172.mp4 | | 叢書(shū)名稱(chēng) | NATO Science Series A: | | 圖書(shū)封面 |  | | 描述 | The purpose of this workshop was to assess the value of DNA polymorphisms for the prediction, diagnosis or elucidation of aetiology for common metabolic diseases such as diabetes, hyperlipidaemia and atherosclerosis. The advent of recombinant DNA techniques has produced an explosion in knowledge of restriction site polymorphisms and hypervariable sequences around candidate genes for such common metabolic diseases as atherosclerosis, hyperlipidaemia and diabetes mellitus. These diseases are the major causes of morbidity and mortality in Western societies today. Since 1983 it has become apparent that there is much more variation in the frequency and sites of these DNA polymorphisms in human populations than was initially appreciated and that the majority of these DNA polymorphisms are only linkage markers for the disease. Consequently it was considered timely for laboratories involved in the mapping of these DNA mutations to meet together to discuss the implications of their studies. The main issues are whether such DNA polymorphisms will lead to an identification of major aetiological loci and which are the best techniques to achieve this? What is the cause of the differences in fre | | 出版日期 | Book 1991 | | 關(guān)鍵詞 | DNA; Lipid; atherosclerosis; coronary heart disease; genes; genetics; heart; heart disease; high-density lip | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-4615-3690-1 | | isbn_softcover | 978-1-4613-6640-9 | | isbn_ebook | 978-1-4615-3690-1 | | copyright | Springer Science+Business Media New York 1991 |
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