Titlebook: DNA Methylation and Cancer Therapy; Moshe Szyf Book 2005 Springer-Verlag US 2005 DNA.Expression.Microarray.Purine.enzymes.gene expression.

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The Role of Active Demethylation in Cancer and Its Therapeutic Potential,s-associated genes. Thus, anticancer therapy directed at DNA methyltransferase might have the untoward effect of promoting metastasis. Inhibition of demethylase activity on the other hand could potentially inhibit metastasis. It is therefore important to identify and characterize the enzymes responsible for global hypomethylation in cancer.

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Purine Analogues and Their Role in Methylation and Cancer Chemotherapy,tween purine and pyrimidine nucleotide metabolism, cell proliferation and tumor cell differentiation, inhibition of key enzymes in nucleotide metabolism and DNA synthesis can be used as a chemotherapeutic approach to treating cancer.