Titlebook: DNA Methylation; Biochemistry and Bio Aharon Razin (Chairman),Howard Cedar,Arthur D. Rig Book 1984 Springer-Verlag New York Inc. 1984 Activ

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DNA Methylation Patterns: Formation and Biological Functions,f these endonucleases is refractory to methylation at their recognition sites (see Chapter 5). The methylation is carried out by sequence-specific modification enzymes, which can methylate efficiently the restriction enzyme recognition sites of the host DNA. Since this methylation must provide prote

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Specific Promoter Methylations Cause Gene Inactivation,ent that the absence of DNA methylation is a necessary—but not sufficient—precondition for gene expression (van der Ploeg and Flavell, 1980; Kuhlmann and Doerfler, 1982; Ott .. 1982). The biochemical mechanisms underlying the regulatory function of DNA methylation are still completely unknown. Obvio

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Chromatin Structure and Gene Expression,tend and loop out from the chromosome axis. Biochemical analyses of chromatin also have revealed changes in the composition of histone and nonhistone proteins that correlate not only with the transcriptional activity of a region of chromatin, but also with its chromatin structure. Similarly, the dis

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Book 1984lecular setting of living sys- tems. It might be said that these few decades have replaced a near vacuum of information with a very large surplus. It is in the context of this flood of information that this series of monographs on molecular biology has been organized. The idea is to bring together i