Titlebook: DNA Methylation; Biochemistry and Bio Aharon Razin (Chairman),Howard Cedar,Arthur D. Rig Book 1984 Springer-Verlag New York Inc. 1984 Activ

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Specific Promoter Methylations Cause Gene Inactivation,hose controlling the expression of eukaryotic genes. Methylated bases (i.e., 5-methylcytosine [5-meCyt] residues) in eukaryotes constitute this type of conspicuous signal. As amply documented in this volume, the introduction of methylated nucleotides into a DNA sequence may serve different functions

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X Inactivation, DNA Methylation, and Differentiation Revisited,hould affect protein-DNA interactions; 2) methylation patterns and a maintenance methylase should exist; and 3) DNA methylation should be involved in mammalian cellular differentiative processes. Holliday and Pugh (1975) argued similarly, although less weight was given to X inactivation and more wei

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Chromatin Structure and Gene Expression,NA in a structure called the nucleosome. Since that time, a vast effort has been made to define more completely the structure, composition, and organization of DNA and proteins within the nucleus. This effort has resulted in a detailed understanding of histone-histone and histone-DNA interactions wi

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Gene Methylation Patterns and Expression,micals that cause demethylation (e.g., 5-azacytidine [5-aza-C]), thereby changing the methylation pattern of the cellular genome (see Chapter 9). Using the proper selection techniques, the expression of particular genes following hypomethylation can be assayed. This method is limited, however, by th

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Jamie Snook,Ashlee Cunsolo,Robyn Morriss a role in directing mismatch repair systems to the correct strands in newly replicated DNA. However, in many bacterial strains, a substantial fraction can be identified with host-specific restriction-modification (RM) systems. These ubiquitous systems play an important biological role in protectin

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