Titlebook: DNA Damage and Repair in Human Tissues; Betsy M. Sutherland,Avril D. Woodhead Book 1990 Plenum Press, New York 1990 DNA.Laboratory.Xeroder

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DNA Damage and Repair in Human Skin: Pathways and Questionsmoters, and modifiers of biological responses to such agents. DNA is the principal target for most carcinogens, and DNA in skin is particularly at risk. It is subject to damage not only from ingested compounds and their metabolic products, but also from externally applied or encountered chemicals, a

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Unscheduled DNA Synthesis in Human Skinr role in the initiation of UV carcinogenesis (Epstein, 1970; Robbins et al., 1974; Hart et al., 1977; Black and Chan, 1977). The repair of these DNA lesions has been widely studied in the recent past (Sutherland et al., 1980) but relatively little information is available on DNA repair in situ in h

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Damage Specific Mammalian Endonucleasesmoved. Modified bases in DNA can be excised from DNA by different repair pathways. The process of excision repair involves four major steps: incision, excision, DNA synthesis, and ligation of the repaired sequence. The enzymes responsible for the first step in this scheme are damage-specific enzymes

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The Significance of DNA Damage and Repair Mechanisms in Health Risk Assessmentthe macromolecular adduct, DNA repair processes play an important role in removing this initial damage in an attempt to assure cellular proliferation and survival. There has been a rapid increase in our knowledge of DNA damage and repair mechanisms over the last several years, using the tools of mol

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Measurements of Genomic and Gene-Specific DNA Repair of Alkylation Damage in Cultured Human T-Lymphonderstand the mechanism and efficiency of DNA repair in human cells. Most of the mechanisms which have been proposed for the repair of various types of damage in human cells has been based upon prokaryotic models (Friedberg, 1985); however, our knowledge of DNA repair processes in human cells is not

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Variability in DNA Repair in Human Skinigher incidence in individuals who spend more time outdoors (Urbach et al., 1972) point to the sun as a major etiologic agent. For melanoma, there is a good correlation of rates of mortality with latitude (Mason and Mckay, 1974). However, the relationship between solar UV radiation exposure and cutaneous melanoma is not simple (Sober, 1987).

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Vanessa Miller,Jens U. P?tzmannn the incidence of skin cancers. It also seems reasonable to suppose that the possible depletion of the stratospheric ozone layer, over populated areas of the earth’s surface, would result in a further long-term increase of skin cancer (van der Leun, 1988).