Titlebook: DNA Damage and Repair; Amleto Castellani Book 1989 Springer Science+Business Media New York 1989 DNA.DNA repair.Nucleotide.biological.biol

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Selective DNA Repair in the Transcribed Strands of Active Genes in Mammalian Cells,ii) In repair proficient human cells, dimers are removed more rapidly from the active DHFR gene than from bulk DNA or from the nontranscribed repetitive alpha sequences (Mellon et al., 1986). This work was recently reviewed by Smith (1987).

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DNA Alkylation Adducts in Human Cells Attributable to Exposure to Alkylating Agents,ese adducts to the process of carcinogenesis. In addition, these measurements, particularly if they reflect long-term exposure to carcinogens could result in an increase in the specificity and sensitivity of epidemiological studies.

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Alan A. D. Peatfield,Christine Morrisby the fact that DNA damaging agents usually form not one, but many DNA lesions. As a result, it is a challenging task to assess the relative contributions of individual DNA adducts to the biological endpoint of mutation.

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Della A. Scott-Ireton,David Gaimsterboratories to clone the yeast genes involved in excision repair, with particular emphasis on the 5 genes which appear to be absolutely required for this process. The cloned genes can then be used to overexpress and purify specific Rad proteins, and hence to attempt to understand the biochemistry of

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https://doi.org/10.1007/978-981-32-9248-2 XP cells a transient correction of the defect was accomplished by micro-injection of cell-free extracts from wild-type sources. Some properties of the factor correcting XP cells from complementation group A are described..Micro-injection was also used to introduce the yeast photo-reactivating enzym

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Laura Miotti,Lucía Magnin,Enrique Terranovaployed are the same in prokaryotes and eukaryotes. For example, an alkyltransferase which transfers in a stoichiometric fashion the methyl group from the oxygen 6 of guanine to a cysteine thiol in the protein has been identified. along with a glycosylase activity capable of excising alkyl groups fro