Titlebook: DNA Damage and Repair; Amleto Castellani Book 1989 Springer Science+Business Media New York 1989 DNA.DNA repair.Nucleotide.biological.biol

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The Latin American Studies Book Seriesin providing a marker of exposure to carcinogenic agents at an individual level and secondly in providing an insight on the biological relevance of these adducts to the process of carcinogenesis. In addition, these measurements, particularly if they reflect long-term exposure to carcinogens could re

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Laura Miotti,Lucía Magnin,Enrique Terranovaing nitrogen atoms of DNA bases, and on oxygen atoms of the phosphate groups to generate a variety of adducts. Two major pathways for the repair of alkylation damage have been identified. The removal of O.-methylguanine (O.-meG) adducts proceeds . the transfer of the alkyl group to a cysteine residu

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Christine S. VanPool,Todd L. VanPooling species. A small group of all HD patients eventually develop acute nonlymphocytic leukemia (ANLL) some years after therapy (t-ANLL). We therefore initiated a study of the O. methylguanine DNA methyltransferase (MT) activity in normal controls and in patients with HD, ANLL . or t-ANLL. As part of

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Christine S. VanPool,Todd L. VanPools such as alkylpyrimidines. Some of them are repaired by alkyl DNA transferase while others are repaired by DNA glycosylases which generate as products the free alkylated base and an apurinic site (AP-site). This is a secondary lesion which is harmful to the cell and is actively repaired. Alkylation

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Alan A. D. Peatfield,Christine Morrists. Misreplication or misrepair of DNA adducts can lead to mutations, which in turn can act as the genetic precursors of cancer and other genetic diseases. A problem in contemporary cancer biology has been to discern the mechanisms by which DNA adducts lead to mutations. This problem is complicated

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Ethnoarchaeological and Historical Methods,ing sunlight exposure, as well as the ability of cells in skin to repair or circumvent such damage. Although repair has been studied extensively in procaryotic and eucaryotic cells—including human cells in culture—there are important differences between repair by human skin cells in culture and huma

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Luise Albrecht,Marina D?ring-Williamsids constructed to permit both replication in bacteria and utilization of human host cell enzymes for expression or replication were used. Plasmids were treated with UV . permitting precise quantification of the extent of damage and selective reversal of dimers by photolyase. The treated plasmids we