Titlebook: DNA Damage and Repair; Advances from Phage Jac A. Nickoloff,Merl F. Hoekstra Book 2001 Springer Science+Business Media New York 2001 DNA.D

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Structure and Functions of the Major Human AP Endonuclease HAP1/Ref-1, a consequence of the absence of the sugar 2′ oxygen in DNA compared to RNA. It has been calculated that up to 10,000 bases (primarily purines) are lost per human cell per day (reviewed in .,.,.,.,.). Because unrepaired AP sites are potentially both cytotoxic and mutagenic (noncoding), this burden o

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Mating-Type Control of DNA Repair and Recombination in ,,haploid cells, and ...α in diploid cells. .α and . a each have two open reading frames, but functions have only been identified for three gene products, Mat.1p, Matα1p, and Matα2p. The . gene products are key regulators of the different stages of the yeast life cycle (reviewed in refs. .,.,.). The M

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The MRE11-RAD50 Complex,been dramatic. This is attributable in part to the analysis of DSB repair-deficient rodent cell lines, which led to the isolation and characterization of the DNA-PK complex, XRCC4, DNA ligase IV, and others .. The gene products thus identified have provided many important insights regarding the func

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DNA Repair and the Generation of Immune Diversity,his task, lymphocytes express clonally unique antigen receptors that transduce signals that activate humoral (B cell) or cellular (T cell) effector functions upon recognition of a suitable antigenic ligand. Lymphocytes require the faithful execution of DNA repair processes first to generate, and the

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Ultraviolet Light-Induced and Spontaneous Recombination in Eukaryotes,15, and refs. .). UV damage can result in genetic mutations that may promote tumorigenesis (.). Indeed, solar UV is the primary cause of skin cancer, the most prevalent form of cancer (.). There is concern about loss of the stratospheric ozone layer, which may result in additional exposure of the ea

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Telomeres, DNA Repair Proteins, and Making Ends Meet,n his classic studies of the fruit fly .. He coined the name ‘telomere’ from the Greek—. meaning end and . meaning part—based on their chromosome end protection function. Shortly thereafter, Barbara McClintock’s cytogenetic observations in maize demonstrated that broken chromosomes could fuse with o