Titlebook: Cytoskeleton of the Nervous System; Ralph A. Nixon,Aidong Yuan Book 2011 Springer Science+Business Media, LLC 2011

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Tauopathy and Brain Aging,ion, and NFTs can be thought of as a tombstone of neuronal dysfunction. Changes in tau may be involved in brain aging and may consequently lead to the formation of NFTs in the entorhinal cortex. This chapter introduces the mechanisms underlying neurodegeneration and brain aging that occur through ta

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Structure of Neural Intermediate Filaments,ural IF can also be deduced, primarily from the pattern of cross-links induced between molecules. Using scanning transmission electron microscopy (STEM) and cryo-tomographic data, the neural IF are likely to have a four-protofibril structure containing 32 chains in section. Assembly occurs through a

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Neurofilament Changes in Multiple Sclerosis,or protein within the axon. Mechanisms of axonal pathology in multiple sclerosis remain unknown, but inflammation in the acute disease phases is likely to cause significant damage. There is also evidence that axonal loss may continue even in the absence of inflammation. It has been postulated that a

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